Unexplained Infertility

What is Unexplained Infertility?

If you’ve been struggling to conceive for more than a year, and reasons for pregnancy delays are still unclear after fertility assessments, tests, and investigations, it could point to a diagnosis of unexplained infertility.

However, rest assured that even with an unexplained infertility diagnosis, there are many modern fertility treatments available to help you on a path to parenthood. Learn more about the diagnosis of unexplained infertility and treatments to overcome the diagnosis below.

What are unexplained infertility treatment options?

Once a diagnosis of unexplained infertility has been reached, your Fertility Specialist will develop a treatment pathway specific to your goals and individual circumstances. Factors such as your age, length of time trying, family goals and other circumstances are important will be discussed to decide the best course of action.

Below are a few fertility treatment options involving assisted reproductive technologies.

Fertility Medication

Simple ovulation induction with an oral fertility drugs such as letrozole.

IUI Treatment

Intrauterine insemination involves inserting the male partner’s (or donor’s) prepared semen through the neck of the womb (cervix) and into the uterus, close to the time of ovulation.

Couples may be recommended to try IUI as a starting point, which can help get the sperm closer to the eggs at the right time.

IVF Treatment

IVF is one approach that can help couples with unexplained infertility where the eggs and sperm are be joined together outside the body, in a specialised laboratory.

The fertilised egg (embryo) grows in a protected environment for some days before being transferred into the woman's uterus, increasing the chance that a pregnancy will occur.

Another benefit of doing IVF alongside a diagnosis of unexplained infertility is that it provides your fertility specialist and laboratory team with a lot more information to determine what may be causing pregnancy delay, since they are able to see the eggs and sperm interact together outside of the body and monitor fertilisation.

There are other specialised treatments and scientific techniques that can be explored alongside IVF, such as Pre-implantation Genetic Testing of embryos, or PGT.

It is strongly recommended you seek assistance after 6 months of trying if you are over the age of 35, and after 12 months of trying if you are under 35.

At IVFAustralia, we have fertility specialists who are experts in the area of unexplained infertility. Meet our dedicated specialists here, and to book an initial consultation call 1800 111 483.

Unexplained Infertility FAQ's

What could cause unexplained infertility?

We don’t know. That’s why it’s such a mystery.  Some experts have speculated that factors such as impaired sperm quality or poor egg quality or an un-receptive uterus may be involved but for most cases, there is simply no explanation.

Can unexplained infertility cases be treated?

Remember that with unexplained infertility, a natural conception is possible at any time (even after years of trying naturally), so you should keep trying and keep the door open for something wonderful to happen. Couples with unexplained infertility can sometimes improve their chances of conception, through fertility drugs or assisted reproductive technology such as IUI and IVF.

What percentage of infertility is unexplained?

A diagnosis of unexplained infertility is surprisingly common. It’s estimated that approximately 10 – 20% of couples experiencing infertility are unexplained.

Watch the informative video below, featuring one of IVFAustralia's leading experts in the area of unexplained infertility, A/Prof Gavin Sacks:

Unexplained Infertility, Explained